Molecular modeling of β-cyclodextrin inclusion complexes with pharmaceutical compounds
نویسندگان
چکیده
منابع مشابه
Molecular modeling of β-cyclodextrin inclusion complexes with pharmaceutical compounds
Ten molecularly diverse compounds, selected on the basis of the standard free energy of complexation with β-cyclodextrin, have been used as training set of molecular docking experiments. After the conformational search of each compound the Molecular Interaction Evaluation (MOLINE) program has been adopted to generate the inclusion geometries. The recognition process has been thermodynamically e...
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Electrochemistry of cyclodextrins (CDs) and cyclodextrin inclusion complexes with different pharmaceutical compounds is reviewed. The article highlights some electrochemical investigations of the CD-drugs interactions in solution. Cyclodextrin modified electrodes and their applications as electrochemical sensors in pharmaceutical analysis based on the self-assembly of CD derivatives on metal el...
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Silymarin is a hepatoprotective agent, having poor water solubility and oral absorption of about 23 - 47%, leading to low bioavailability of the drug. The aim of the present study is to improve the solubility and dissolution rate and in turn the hepatoprotective activity of the drug, by formulating its inclusion complex with beta (β)-cyclodextrin, using different methods. The phase solubility a...
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One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is toform inclusion complexes with β-cyclodextrin. The formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. The aqueous phasesolubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. The studyof thermodynamic parameters like ΔG,...
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Formation of inclusion complexes of monochlorotriazinyl-β-cyclodextrin with promethazine was studied, for establishing the optimal conditions of their formation, in view of subsequent grafting on cellulose textiles with potential medicinal use. The infrared spectral study of inclusion in solid state indicated that the complex can be even formed by physically mixing the two substances. By the co...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2004
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0005.511